Both flunarizine and propranolol are useful drugs for migraine prophylaxis and can be used effectively as first-line drugs.
How it works
Mibeta contains Propranolol, Non-Selective β-blockers and flunarizine, H1-receptor blocker & calcium-channel blocker used to reduce the severity and frequency of migraine headaches
Flunarizine helps to reduce the frequency of migraine attacks and to a lesser extent the severity of the attacks.
Indications
Both flunarizine and propranolol are useful drugs for migraine prophylaxis and can be used effectively as first-line drugs.
Dosage
Twice a day
Side Effects
Propranolol: Cold extremities, insomnia, fatigue, dizziness, nausea, constipation or diarrhoea, vomiting, anorexia, stomach discomfort, impotence. Weakness, paraesthesia, wheezing, pharyngitis, bronchospasm. CNS disturbances at higher doses and mood alterations. Depression, confusion, cognitive dysfunction, emotional lability, fatigue, hallucinations.
Flunarizine: Drowsiness. Rarely wt gain, headache, depression, gastric pain, dry mouth, insomnia, extrapyramidal reactions, galactorrhoea.
Contraindication
Propranolol:
Sinus bradycardia, cardiogenic shock, sick sinus syndrome, Raynaud’s syndrome, 2nd and 3rd degree heart block, overt CHF, bronchial asthma, COPD, untreated phaeochromocytoma, Prinzmetal’s angina; severe peripheral arterial disease, metabolic acidosis. Concomitant use w/ thioridazine.
Flunarizine:
Pregnancy, lactation, GI or urinary tract obstruction, acute porphyrias.
Mibeta Plus is contraindicated in Pregnancy & Lactation
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