Migraine Pain & associated symptoms of Nausea & Vomiting
How it works
Naproxen Sodium is a Nonsteroidal Anti-Inflammatory Drug (NSAID) of the propionic acid class and is commonly used for relief of a wide variety of pain, fever, swelling and stiffness.
Domperidone, is a medication which developed specifically to block dopamine receptors.. Domperidone is given in order to relieve nausea and vomiting. It is also used in the scientific study of the way dopamine (an important neurotransmitter) acts in the body.
Indications
Migraine Pain & associated symptoms of Nausea & Vomiting
Dosage
Twice daily
Side Effects
Naproxen
Peripheral oedema, CHF, palpitations, vasculitis, tachycardia, dyspnoea; constipation, heartburn, abdominal pain, nausea; headache, drowsiness, dizziness, vertigo, lightheadedness, inability to concentrate, mental depression, nervousness, irritability, fatigue, malaise, insomnia, sleep disorders, dream abnormalities, aseptic meningitis; tinnitus, hearing or visual disturbances; thrombocytopenia, leucopenia, granulocytopenia, eosinophilia, agranulocytosis, aplastic anaemia, haemolytic anaemia; glomerulonephritis, interstitial nephritis, nephrotic syndrome, abnormal LFT; pruritus, rashes, skin eruptions, ecchymoses, myalgia, muscle weakness and cramps.
Potentially Fatal: Anaphylactic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, MI, stroke, GI haemorrhage and perforation, jaundice and/or fatal hepatitis, renal failure.
Domperidone
Dry mouth; increased prolactin levels (dose dependent) which may lead to galactorrhoea, amenorrhoea, gynaecomastia; breast pain and tenderness; convulsions, dystonic reactions; urticaria, rash, pruritus; transient intestinal cramps, diarrhoea; nervousness, anxiety, decreased libido, asthenia, headache, agitation; oculogyric crisis, urinary retention. Rhythm and heart rate disorders; increased QT interval, atrial fibrillation, arrhythmia, palpitation, ventricular tachycardia, bradycardia; abnormal LFT.
Potentially Fatal: Serious ventricular arrhythmia, sudden cardiac death, torsade de pointes, anaphylaxis, angioedema.
Contraindication
Naproxen
Hypersensitivity to naproxen, aspirin or other NSAIDs. Treatment of perioperative pain in the setting of CABG surgery. Active or history of peptic ulceration or active GI bleeding. History of asthma, urticaria, allergic-type reactions. Severe renal impairment.
Domperidone:
Patients w/ prolactin-releasing pituitary tumour, GI haemorrhage, mechanical obstruction or perforation; chronic admin or routine prophylaxis of post-op nausea and vomiting. Concomitant use w/ potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin or ritonavir).
Pregnancy:
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
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