Partial seizures
Epilepsy
How it works
Clobazam binds to one or more specific GABA receptors at several sites within the CNS including the limbic system and reticular formation. Increased permeability of neuronal membrane to chloride ions results in GABA’s inhibitory effect leading to hyperpolarisation and stabilisation.
Indications
Partial seizures
Epilepsy
Dosage
Twice In A Day or As Per Requirement
Side Effects
Constipation, anorexia, nausea; dizziness, fine tremors; worsening of respiratory symptoms in predisposed individuals; ataxia, drowsiness, headache, confusion; loss of libido, motor dysfunction; dependence; visual disturbances and weight gain
Contraindication
Hypersensitivity; history of drug dependence; myasthaenia gravis; pregnancy (1st trimester), lactation; serious liver damage; sleep apnoea syndrome; impaired respiratory function.
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