Monotherapy & adjunctive therapy in the treatment of complex partial seizures, Sole & adjunctive therapy in the treatment of simple & complex absence seizures, Prophylaxis of migraine headaches.
How it works
Divalproex sodium is a stable coordination compound comprised of sodium valproate and valproic acid used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches.Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. It has been suggested that its activity in epilepsy is related to increased brain concentrations of gamma-aminobutyric acid (GABA).
Indications
Monotherapy & adjunctive therapy in the treatment of complex partial seizures, Sole & adjunctive therapy in the treatment of simple & complex absence seizures, Prophylaxis of migraine headaches.
Dosage
Dosage should be individualized. VAP-DXR is for once daily administration and should be swallowed whole and should not be crushed or chewed.
Complex Partial Seizures: Adults and Children ≥10 years : Patients should initiate therapy at 10-15 mg/kg/day. The dosage should be increased by 5-10 mg/kg/week to achieve optimal clinical response. Ordinarily, optimal clinical response is achieved at daily doses <60 mg/kg/day
Simple and Complex Absence Seizures: Adults and Children ≥10 years: Recommended Initial Dose: 15 mg/kg/day, increasing at 1-week intervals by 5-10 mg/kg/day until seizures are controlled or side effects preclude further increases. The maximum recommended dose is 60 mg/kg/day.
Side Effects
Nausea, dyspepsia, diarrhoea, vomiting, abdominal pain, respiratory infection, somnolence, infection, increased appetite, weight gain.
Contraindication
Hypersensitivity, Known urea cycle disorders, Hepatic disease or significant hepatic dysfunction.
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