Multi- drug resistant epilepsy
Migraine prophylaxis
Adjunct with alcohol withdrawal therapy
How it works
Topiramate is an anticonvulsant (antiepilepsy) drug. Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. It is also Food and Drug Administration (FDA) approved for, and most frequently prescribed for, the prevention of migraines. Topiramate in TOPATE is a sulfamate-substituted monosaccharide with precise mechanism of action unknown. It may be due to various mechanisms e.g. blocking of voltage-dependent sodium channels; augmenting the activity of γ-aminobutyric acid (GABA) at GABA-A receptor; antagonising AMPA/kainate glutamate receptors; inhibiting carbonic anhydrase.
Indications
Multi- drug resistant epilepsy
Migraine prophylaxis
Adjunct with alcohol withdrawal therapy
Dosage
As monotherapy in Epilepsy
Initially, 25 mg at night for 1 week, thereafter increase in steps of 25-50 mg at intervals of 1-2 wk.
Doses >25 mg/day should be taken in 2 divided doses.
Usual dose: 100-400 mg daily.
Max: 400 mg daily
Migraine prophylaxis
Adult: >16 yr: Initially 25 mg daily at night for 1 wk, increased in steps of 25-mg at wkly intervals.
Usual dose: 50-100 mg daily in 2 divided doses.
Daily doses >25 mg should be taken in 2 divided doses
Side Effects
Confusion, dizziness, drowsiness, generalised slowing of mental and physical activity, difficulty with concentrations, ataxia, paresthesia, anorexia, weight loss, abnormal vision, metabolic acidosis, mood or mental changes, behavioural disturbances, depression, fatigue, agitation, nervousness, anxiety, oligohidrosis, hyperthermia and hyperammonaemic encephalopathy.
Contraindication
This is contraindicated in pregnant and lactating woman.
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