How it works

Gabapentin, is an anticonvulsant drug used for neuropathic pain. Gabapentin is structurally related to the neurotransmitter GABA but is neither a GABA agonist nor antagonist. High affinity gabapentin binding sites are located throughout the brain. These sites correspond to the presence of voltage-gated Ca channels particularly controlling the α-2/δ-1 subunit. This channel appears to be located presynaptically and may modulate the release of excitatory neurotransmitters which participate in epileptogenesis and nociception.

Methylcobalamin is the active form of vitamin B 12 i.e. cyanocobalamin which is used to prevent or treat disorders arising from the deficiency of vitamin B12, such as Neuropathy. As compared with cyanocobalamin, methylcobalamin has faster onset of action in repair / regeneration of damaged neurons, particularly the myelin sheath. Methylcobalamin is used in the treatment of peripheral neuropathy and diabetic neuropathy, as it plays a vital role in the metabolism of fatty acids essential for the maintenance of nerve myelin.

Nortriptyline is a metabolite of amitriptyline with several pharmacological mechanisms including blockade of norepinephrine and serotonin uptake, blockade of sodium channels, and sympathetic blockade and antagonism of N-methyl-D-aspartate glutamate (NMDA) receptors.

Lidocaine: Belongs to the family of medicines called local anesthetics. Lidocaine prevents pain by blocking the signals at the nerve endings in the skin. Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.