High Blood Pressure
How it works
Olmesartan is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Olmesartan selectively inhibits the binding of angiotensin II to AT1, which is found in many tissues such as vascular smooth muscle and the adrenal glands. This effectively inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure. Olmesartan is selective for AT1 and has a 12,500 times greater affinity for AT1 than the AT2 receptor.
Indications
High Blood Pressure
Dosage
1 tab. ONCE IN A DAY
Side Effects
Dizziness, itching, skin rash, difficulty in breathing or swallowing.
Contraindication
Patients who are hypersensitive to this drug or to any ingredient in the formulation.
Concomitant use of angiotensin receptor antagonists (ARBs) including olmesartan with aliskiren-containing drugs in patients with diabetes mellitus (type 1 or type 2) or moderate to severe renal impairment (GFR <60mL/min/1.73 m2)
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