NORMALIP AS

(Rosuvastatin 10, 20 mg + Aspirin 75mg Capsule)

Cardiology

NORMALIP AS

(Rosuvastatin 10, 20 mg + Aspirin 75mg Capsule)

Cardiology

Indications

For the treatment of dyslipidemia associated with artherosclerotic arterial disease with risk of myocardial infarction, stroke or peripheral vascular disease.

How it works

Rosuvastatin is a selective and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of cholesterol. It increases the number of hepatic low-density lipoprotein (LDL) receptors on the cell-surface to enhance uptake and catabolism of LDL. Also, rosuvastatin inhibits hepatic synthesis of very-low-density lipoprotein (VLDL), which reduces the total number of VLDL and LDL particles.
Aspirin is a more potent inhibitor of both prostaglandin synthesis and platelet aggregation than other salicylic acid derivatives. The differences in activity between aspirin and salicylic acid are thought to be due to the acetyl group on the aspirin molecule. This acetyl group is responsible for the inactivation of cyclo-oxygenase via acetylation.
Aspirin affects platelet aggregation by irreversibly inhibiting prostaglandin cyclo-oxygenase. This effect lasts for the life of the platelet and prevents the formation of the platelet-aggregating factor thromboxane A2. Non-acetylated salicylates do not inhibit this enzyme and have no effect on platelet aggregation. At somewhat higher doses, aspirin reversibly inhibits the formation of prostaglandin I2 (prostacyclin), which is an arterial vasodilator and inhibits platelet aggregation.
At higher doses, aspirin is an effective anti-inflammatory agent, partially due to inhibition of inflammatory mediators via cyclo-oxygenase inhibition in peripheral tissues. In vitro studies suggest that other mediators of inflammation may also be suppressed by aspirin administration, although the precise mechanism of action has not been elucidated. It is this non-specific suppression of cyclo-oxygenase activity in peripheral tissues following large doses that leads to its primary side effect of gastric irritation.

Indications

For the treatment of dyslipidemia associated with artherosclerotic arterial disease with risk of myocardial infarction, stroke or peripheral vascular disease.

Dosage

OD/BD

Side Effects

Increased bleeding tendency, Nausea, Abdominal pain, Headache, Constipation, Muscle pain, Weakness, Dizziness, Indigestion

Contraindication

Hypersensitivity to rosuvastatin, aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), salicylic acid compounds, prostaglandin synthetase inhibitors or to any of the excipients
Patients with the syndrome of asthma with rhinitis and/or nasal polyps as aspirin may cause severe urticaria, angioedema or bronchospasm (asthma)
Active liver disease, which may include unexplained persistent elevations of hepatic transaminase levels
Active, or history of recurrent peptic ulcer and/or gastric/intestinal hemorrhage or other kinds of bleeding such as cerebrovascular hemorrhages
Hemorrhagic diathesis, coagulation disorders such as hemophilia and thrombocytopenia
In children or teenagers for viral infections, with or without fever, because of the risk of Reye’s syndrome with concomitant use of aspirin in certain viral illnesses.
In patients with myopathy
In patients receiving concomitant cyclosporine
Methotrexate used at doses >15 mg/week
Severe renal impairment
Women who are pregnant or may become pregnant
Lactation

Technical information

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Cardiology

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