Hypertension
Hypertension associated with palpitation
Hypertension associated with edema
How it works
Losartan belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
Indications
Hypertension
Hypertension associated with palpitation
Hypertension associated with edema
Dosage
Hypertension
Adult : Initially, 25 mg once daily
Followed by 50 mg once daily, may increase to 100 mg/day as single dose or in 2 divided doses if needed.
Elderly: >75 yr initially, 25 mg/day.
Hepatic impairment: Mild or moderate: Initially, 25 mg once daily. Severe: Contraindicated.
Diabetic nephropathy in Type 2 diabetes mellitus
Adult: Initially, 50 mg once daily, may increase to 100 mg once daily depending on BP response.
Elderly: >75 yr Initially, 25 mg/day.
Hepatic impairment: Mild or moderate: Initially, 25 mg once daily. Severe: Contraindicated.
Heart failure
Adult: Initially, 12.5 mg once daily, may be doubled at wkly intervals. Maintenance: 50 mg once daily. Max: 150 mg once daily if tolerated.
Side Effects
Upper resp infection, nasal congestion, sinusitis, headache, dizziness, back pain, leg pain, muscle cramps, asthenia or fatigue, neutropenia, chest pain, cough, bronchitis, UTI, diarrhoea, gastritis, anaemia, hypoglycaemia, diabetic vascular disease, cataracts, cellulitis, hyperkalaemia, myalgia, arthralgia, hypotension, muscular weakness, hypoaesthesia, infection, knee pain. Rarely, pruritus, rash, urticaria, angioedema, elevated liver enzyme values, rhabdomyolysis.
Contraindication
Concomitant use w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min). Severe hepatic impairment. Pregnancy.
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