( Sodium picosulphate 3.33 mg + Milk of magnesia 3.75 ml + Liquid paraffin 1.25 ml / 5 ml syrup)
( Sodium picosulphate 3.33 mg + Milk of magnesia 3.75 ml + Liquid paraffin 1.25 ml / 5 ml syrup)
Idiopathic constipation
Constipation in diabetics
Habitual constipation
Opiod-induced constipation
Bowel preparation before colonoscopy
Pre and post operative condition
Constipation in elderly and bed-ridden patients
How it works
Sodium picosulphate:
It is hydrolysed by colonic bacteria to the active form, which then acts locally to irritate the mucosa and activate myentric neurons, thus increases the bowel movement. Along with magnesium salts, it has been used to evacuate the colon for colonoscopy or surgery.
Milk of magnesia:
It is an aqueous suspension of magnesium hydroxide (8 % w/w suspension). As a suspension in water, it is often called milk of magnesia because of its milk-like appearance. It has low water solubility. It is not absorbed in the intestine and retains water osmotically, thus increasing peristalsis and also provides laxative action.
Liquid paraffin:
It is a viscous liquid, a mixture of hydrocarbons.When taken orally, it acts as a lubricant and stool softener and eases the passage of stools.
Indications
Idiopathic constipation
Constipation in diabetics
Habitual constipation
Opiod-induced constipation
Bowel preparation before colonoscopy
Pre and post operative condition
Constipation in elderly and bed-ridden patients
Dosage
1-2 tablespoonful at bedtime with adequate amount of water.
Side Effects
Sodium picosulphate: Stomach pain, diarrhea, nausea
Milk of magnesia: Weakness, nausea, vomiting.
Liquid paraffin: Anal seepage or irritation, granulomatous reactions, pneumonia – this may happen if this medicine is accidentally inhaled
Contraindication
Sodium picosulphate:
Patients who have an obstruction of the intestine (gut)
Paralytic ileus (lack of bowel movements, leading to blockage of the gut)
Abdominal pain plus feeling sick (nausea) or vomiting
Active and severe inflammatory bowel disease
Surgical abdominal conditions (such as appendicitis), or those who are severely dehydrated.
Caution in Children Women who are pregnant or who are breastfeeding
Milk of magnesia:
Contraindicated in patients with renal insufficiency, appendicitis symptoms, acute surgical abdomen, myocardial damage, heart block.
Pregnancy: Category B drug
Lactation: Use in nursing mothers appears to be safe
Liquid paraffin:
Hypersensitivity to liquid paraffin.
It should not be used when abdominal pain, nausea or vomiting is present.
Should not be used during lactation, unless directed by a doctor.
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