Chronic Idiopathic constipation
Laxative Resistant Constipation
Impaired Motility
How it works
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs.Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content.
Indications
Chronic Idiopathic constipation
Laxative Resistant Constipation
Impaired Motility
Dosage
Adults: 2 mg once daily.
Patients with severe renal impairment (creatinine clearance (CrCL) less than 30 mL/min: 1 mg once daily.
Side Effects
The common side effects associated are chest pain or discomfort, confusion, difficulty in speaking, double vision, headache, inability to move the arms, legs, or facial muscles, inability to speak, nausea.
Contraindication
Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal wall.
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