Post Prandial hyperglycemia
Type 2 Diabetes Mellitus
How it works
Alpha-glucosidase inhibitor Voglibose is saccharides that act as competitive inhibitors of enzymes needed to digest carbohydrates: specifically alpha-glucosidase enzymes in the brush border of the small intestines. The membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the small intestine. Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine. Inhibition of these enzyme systems reduces the rate of digestion of complex carbohydrates. Less glucose is absorbed because the carbohydrates are not broken down into glucose molecules. In diabetic patients, the short-term effect of these drugs therapies is to decrease current blood glucose levels: the long term effect is a small reduction in hemoglobin-A1c level.
Indications
Post Prandial hyperglycemia
Type 2 Diabetes Mellitus
Dosage
1-2 Tab just before meals.
Side Effects
Flatulence, abdominal distension, diarrhea, pain, skin reactions, low blood sugar, increased LFT
Contraindication
Hypersensitivity to Voglibose or to any of the excipients.
• Diabetic ketoacidosis, diabetic pre-coma
• Severe infection, before and after operation or with serious trauma.
• Gastrointestinal obstruction or predisposed to it
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