Tiglaz: Teneligliptin 20mg tablet
Tiglaz M: Teneligliptin 20mg + Metformin 500mg SR tablet
Tiglaz DM: Teneligliptin 20mg + Metformin 1000mg SR tablet
Tiglaz: Teneligliptin 20mg tablet
Tiglaz M: Teneligliptin 20mg + Metformin 500mg SR tablet
Tiglaz DM: Teneligliptin 20mg + Metformin 1000mg SR tablet
For the treatment of Type 2 Diabetes Mellitus as a monotherapy/dual therapy adjunct to diet and exercise.
How it works
Teneligliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Concentrations of the active intact hormones are increased by teneligliptin, thereby increasing and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, teneligliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.
Metformin: Helps decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target cell insulin sensitivity. Also used as an adjunct to DPP-4 inhibitors, diet, exercise and lifestyle changes such as weight loss to improve glycemic (blood sugar) control in adults with type 2 diabetes
Indications
For the treatment of Type 2 Diabetes Mellitus as a monotherapy/dual therapy adjunct to diet and exercise.
Dosage
The usual adult dosage is 20 mg of teneligliptin administered orally once daily. If efficacy is insufficient, the dose may be increased up to 40 mg once daily while closely monitoring the clinical course.
Side Effects
Headache, Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea, Upper respiratory tract infection, Nasopharyngitis (inflammation of the throat and nasal passages)
Contraindication
Teneligliptin is contraindicated in the following:
Any patient with a known hypersensitivity to teneligliptin or any of the components in the formulation,
Severe ketosis, diabetic coma or history of diabetic coma, type 1 diabetic patients,
Patients with severe infection, surgery, severe trauma (blood sugar control should preferably be done by insulin).
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