Moderate to severe pain
Symptomatic relief of fever
How it works
Paracetamol (acetaminophen) is a pain reliever and a fever reducer. Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.
Analgesic action is due to inhibition of prostaglandin synthesis. Prostaglandins are chemicals that are released in response to illness or injury and are responsible for causing pain. Paracetamol blocks the production of prostaglandins, making the body less aware of the pain or injury.
Antipyretic action is due to action on hypothalamic heat-regulating center of the brain that reduces body temperature by increasing sweating and heat loss.
Indications
Moderate to severe pain
Symptomatic relief of fever
Dosage
Mild to moderate pain and fever
Adult: 0.5-1 g 4-6 hourly. Max: 4 g daily.
Mild to moderate pain and fever
Adult: 33-50 kg: 15 mg/kg as a single dose, at least 4 hourly. Max: 60 mg/kg (up to 3 g) daily; >50 kg: 1 g as a single dose, at least 4 hourly. Max: 4 g daily. Admin by infusion over 15 min.
Renal impairment:
Hepatic impairment: Max: 3 g/day.
Adults: 650mg upto 1000mg.
Maximum Dose: 4 g daily in divided doses (3-4 times)
Side Effects
nausea, upper stomach pain, itching, loss of appetite
Contraindication
Hypersensitivity to paracetamol.
Special Precautions
Paracetamol should be given with care to patients with:
Impaired kidney or liver function.
Patients taking other drugs that affect liver.
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