Irritable bowel syndrome
Gastrointestinal tract spasm.
How it works
Mebeverine
Mebeverine is an antimuscarinic. It belongs to a group of compounds called musculotropic antispasmodics. These compounds act directly on the gut muscles at the cellular level to relax them. This relieves painful muscle spasms of the gut, without affecting its normal motility. Mebeverine is used to relieve symptoms of irritable bowel syndrome and related intestinal disorders that are the result of spasms in the intestinal muscles. These include colicky abdominal pain and cramps, diarrhoea alternating with constipation and flatulence (wind).
Mebeverine is also an inhibitor of calcium-depot replenishment. Therefore, it has dual mode of action which normalizes the small bowel motility.
Chlordiazepoxide
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation Chlordiazepoxide binds to stereo specific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor. BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
Indications
Irritable bowel syndrome
Gastrointestinal tract spasm.
Dosage
Once or Twice daily therapy
Side Effects
Mebeverine
Indigestion or heartburn
Constipation
Dizziness
Insomnia (difficulty sleeping)
anorexia (loss of appetite)
Headache
Tiredness
Slow heart beat
Rash and/or itchy skin
Chlordiazepoxide
Physical and psychological dependence; withdrawal syndrome; impairs psychomotor performance, aggression (in predisposed individuals especially in combination with alcohol); sedation; jaundice, hepatic dysfunction.
Contraindication
Meberverine
Paralytic ileus (occurrence of intestinal blockage)
Special precaution- Severe hepatic or renal impairment; cardiac disorders e.g. heart block; porphyria. May impair ability to drive or operate machinery.
Use in Pregnancy Category B2 Safe use in pregnancy has not been established with regards to possible adverse effects on foetal development. Therefore Mebeverine tablets are not recommended during the first trimester of pregnancy and otherwise risk-benefit must be considered in its use in pregnant women. Teratogenicity has not been demonstrated in teratology studies in rats and rabbits. Use in Lactation Mebeverine is secreted in breast milk.
Use in Pregnancy
Category B2 Safe use in pregnancy has not been established with regards to possible adverse effects on foetal development. Therefore Mebeverine tablets are not recommended during the first trimester of pregnancy and otherwise risk-benefit must be considered in its use in pregnant women. Teratogenicity has not been demonstrated in teratology studies in rats and rabbits
Use in Lactation Mebeverine is secreted in breast milk. Although problems have not been documented, as a general rule, Mebeverine tablets should not be given to w woman who is breastfeeding unless the anticipated benefits outweigh possible risks.
CHLORDIAZEPOXIDE
Acute pulmonary insufficiency, respiratory depression, patients with marked neuromuscular respiratory weakness; hypersensitivity to benzodiazepines; chronic psychosis.
Pregnancy and Lactation- Contraindicated
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