Ménière’s syndrome
Vertigo
Tinnitus
Hearing loss and
Nausea
How it works
Betahistine dihydrochloride is a histamine analogue. It is a structural analog of HA with weak histamine H1 receptor agonist and more potent histamine H3 receptor antagonist properties.
Betahistine dilates the blood vessels within the inner ear which can relieve pressure from excess fluid and act on the smooth muscle. It increases the level of serotonin in the brainstem inhibits the activity of vestibular nuclei.
Indications
Ménière’s syndrome
Vertigo
Tinnitus
Hearing loss and
Nausea
Dosage
Adults
Initial oral treatment is 8 to 16 mg three times daily, taken preferably with meals.
Maintenance doses are generally in the range 24 – 48 mg daily.
Daily dose should not exceed 48 mg.
Dosage can be adjusted to suit individual patient needs. Sometimes improvement could be observed only after a couple of weeks of treatment.
Side Effects
feeling sick (nausea) indigestion (acid reflux) bloating or mild stomach ache, headache
Contraindication
Betahistine is contraindicated for patients with pheochromocytoma. Patients with bronchial asthma or a history of peptic ulcer need to be closely monitored.
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