Asthma
Rheumatoid arthritis
Dermatomyositis
Nephrotic syndrome
Acute and lymphatic leukemia
Immune suppression in transplantation
How it works
Deflazacort acts within the cells to prevent the release of histamine from mast cells that are important in the immune system. These chemicals are normally involved in producing immune and allergic responses, resulting in inflammation.
Indications
Asthma
Rheumatoid arthritis
Dermatomyositis
Nephrotic syndrome
Acute and lymphatic leukemia
Immune suppression in transplantation
Dosage
Bronchial asthma: In the treatment of an acute attack, high doses of 48 -72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled. For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms.
Side Effects
Indigestion, abdominal bloating, nausea, ulceration in the stomach or intestine, inflammation of the pancreas and throat ulcer.
Contraindication
Systemic infection; live virus vaccines in those receiving immunosuppressive doses.
Pregnancy:
The ability of corticosteroids to cross the placenta varies between individual drugs; however, deflazacort does cross the placenta.
Lactation:
Corticosteroids are excreted in breast milk, although no data are available for deflazacort. Doses of up to 50 mg daily of deflazacort are unlikely to cause systemic effects in the infant
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