(Domperidone 10mg+Paracetamol 325mg) Tablet, (Domperidone 10mg/20mg Dispersible Tablet)
(Domperidone 10mg+Paracetamol 325mg) Tablet, (Domperidone 10mg/20mg Dispersible Tablet)
Migraine
Cluster headaches
How it works
Domperidone is a dopamine antagonist which works to prevent vomiting (symptom of migraine). Domperidone is given with paracetamol, an analgesic, for relief of migraine.
Indications
Migraine
Cluster headaches
Dosage
Adult: 2 tab (20 mg domperidone/1000 mg paracetamol) at onset of migraine attack. Repeat up to every 4 hr if required. Max: 4 g paracatamol/day. Max Dosage: 8 tab (4 doses) in 24 hr.
Side Effects
Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Contraindication
Phaeochromocytoma; children, elderly; renal or hepatic impairment, risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy, lactation and alcohol-dependent patients.
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