How it works

LEVOSULPIRIDE
Levosulpiride is more selective and acts primarily as a dopamine D2 antagonist. Levosulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors. A selective antagonist of dopamine (D2) receptors having activity on both central and peripheral levels. It posses prokinetic and neuroleptic properties.
Dopamine (acting through D2 receptors) is an inhibitory neurotransmitter in GIT which; Delays gastric emptying when food is present in stomach.
Levosulpiride blocks dopamine (D2) receptors and shows opposite effects to dopamine. It Increases gastric emptying Enhances LES (Lower esopharyngeal sphincter) tone. Levosupiride has centrally action on Chemoreceptor trigger zone (CTZ) producing anti-emetic action.
RABEPRAZOLE
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.