LEFIT PLUS

(Levosulpiride 75 mg SR +Rabeprazole 20 mg Tablet)

Gastroenterology

LEFIT PLUS

(Levosulpiride 75 mg SR +Rabeprazole 20 mg Tablet)

Gastroenterology

Indications

GERD, IBS, Functional Dyspepsia, Diabetic Gastroparesis

How it works

LEVOSULPIRIDE
Levosulpiride is more selective and acts primarily as a dopamine D2 antagonist. Levosulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors. A selective antagonist of dopamine (D2) receptors having activity on both central and peripheral levels. It posses prokinetic and neuroleptic properties.
Dopamine (acting through D2 receptors) is an inhibitory neurotransmitter in GIT which; Delays gastric emptying when food is present in stomach.
Levosulpiride blocks dopamine (D2) receptors and shows opposite effects to dopamine. It Increases gastric emptying Enhances LES (Lower esopharyngeal sphincter) tone. Levosupiride has centrally action on Chemoreceptor trigger zone (CTZ) producing anti-emetic action.
RABEPRAZOLE
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.

Indications

GERD, IBS, Functional Dyspepsia, Diabetic Gastroparesis

Dosage

Once in a day 15- 20 minutes before meals.

Side Effects

Headache
Fatigue
Increased prolactin level in blood
Drowsiness
Irregular Menstrual Periods
Gynecomastia
Constipation
Abdominal pain and cramps

Contraindication

Levosulpiride:
Contraindicated in patients with known hypersensitivity to levosulpiride or any of the other constituents of the formulation.
Contraindicated in: epilepsy, manic states, cardiac impairment and GI bleeding.
Pregnancy

Caution when used during pregnancy
Lactation

Caution when used during lactation

Levosulpiride and Other Contraindications
Phaeochromocytoma, hyperprolactinaemia, mammary dysplasia, malignant mastopathies,. GI bleeding, mechanical obstruction or perforation

PREGNANCY AND LACTATION.
Special Precautions: May impair ability to drive or operate machinery.
Rabeprazole:
Hypersensitivity to rabeprazole, or any of components of its pharmaceutical forms.
Pregnancy: FDA Pregnancy Category B
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).
Lactation: Infant risk cannot be ruled out.

Technical information

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Gastroenterology

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