For the topical treatment of superficial fungal infections of skin including tinea pedis.
How it works
Sertaconazole is an antifungal that belongs to the imidazole class of antifungals and exhibits activity similar to that of other imidazoles. It is believed that they act primarily by inhibiting the cytochrome P450-dependent synthesis of ergosterol. Ergosterol is a key component of the cell membrane of fungi, and lack of this component leads to fungal cell injury, primarily by leakage of key constituents in the cytoplasm from the cell.
Additionally sertaconazole has demonstrated broad spectrum of antifungal activity, which includes opportunistic filamentous fungi (e.g. Aspergillus, Alternaria, Scopulariopsis, Fusarium), and pathogenic yeasts such as Malassezia furfur, Candida albicans, Candida tropicalis, Torulopsis, and trichosporon. Activity has also been observed against Trichomonas and some gram-positive organisms (staphylococci, streptococci).
Indications
For the topical treatment of superficial fungal infections of skin including tinea pedis.
Dosage
In the treatment of superficial fungal infections of skin should be applied twice daily for 2 weeks.
In the treatment of interdigital tinea pedis should be applied twice daily for 4 weeks.
If a patient shows no clinical improvement 2 weeks after the treatment period, the diagnosis should be reviewed.
Side Effects
Contraindication
In patients having a known or suspected sensitivity to sertaconazole or to other imidazoles.