For the treatment of dermatomycoses caused by dermatophytes, i.e. tinea pedis, tinea cruris, tinea corporis, tinea manuum. It is also indicated in cutaneous candidiasis and pityriasis versicolor.
How it works
Amorolfine, a morpholine derivative, is the first of a new class of antifungal drugs. The mechanism of action is inhibition of ergosterol biosynthesis in the fungal cell membrane. Alteration in the membrane sterol content leads to changes in membrane permeability and disruption of key fungal metabolic processes.
Indications
For the treatment of dermatomycoses caused by dermatophytes, i.e. tinea pedis, tinea cruris, tinea corporis, tinea manuum. It is also indicated in cutaneous candidiasis and pityriasis versicolor.
Dosage
should be applied to the affected areas once daily (in the evening). The treatment should be continued without interruption until clinical cure, and for several days thereafter. The required duration of treatment depends on the species of fungi and on the localisation of the infection. In general, treatment should be continued for at least 2–3 weeks. In foot mycoses, up to 6 weeks of therapy may be necessary. Based on the results of reported clinical trials, cure can be expected in 80–90% of skin mycoses.
Side Effects
Contraindication
There are no specific studies involving concomitant treatment with other topical medicines.
Use of nail varnish or artificial nails should be avoided during treatment.
An interaction with acenocoumarol has been reported with increase in International Normalised Ratio (INR) values.
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