Used for the treatment of erectile dysfunction.
How it works
Tadalafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, tadalafil works by increasing blood flow to the penis to help a man get and keep an erection.
How it works:
Penile erection during sexual stimulation is achieved by the relaxation of penile arteries and corpus cavernosal smooth muscles, leading to increased blood flow to the organ. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum, and is degraded by the cGMP specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum located around the penis. Tadalafil inhibits PDE5 and thereby enhances erectile function by increasing the amount of cGMP available.
Indications
Used for the treatment of erectile dysfunction.
Dosage
Use as needed for ED:
- Initial dose: 10 mg orally once a day, as needed, prior to sexual activity
- Maintenance dose: 5 to 20 mg orally once a day as needed, prior to sexual activity based on individual efficacy and tolerability
Comment: Consider that this drug has shown to improve erectile dysfunction up to 36 hours following dosing, when used as needed.
Once a day use for ED:
- Initial dose: 2.5 mg orally once a day at approximately the same time, without regard to timing of sexual activity
- Maintenance dose: 2.5 to 5 mg orally once a day based on individual efficacy and tolerability.
Side Effects
Common tadalafil side effects may include: headache; flushing (warmth, redness, or tingly feeling); nausea, upset stomach; stuffy nose; or muscle pain, back pain, pain in your arms, legs, or back.
Contraindication
Copyright © 2020 tasmed
.png)
