(Sulfasalazine 500/1000mg Delayed Release Enteric Coated tablet)
(Sulfasalazine 500/1000mg Delayed Release Enteric Coated tablet)
• Rheumatoid arthritis
• Psoriatic arthritis
• Arthritis associated with inflammatory bowel disease (sometimes known as IBD)
• Juvenile idiopathic arthritis.
How it works
Sulfasalazine is considered a disease-modifying anti-rheumatic drug (DMARD). It can decrease the pain and swelling of arthritis, prevent joint damage, and reduce the risk of long-term disability. Approximately 30 percent of orally administered sulfasalazine, which therapeutically is a relatively inactive chemical, is rapidly absorbed by the small bowel and is then returned, largely unaltered, via the enterohepatic circulation into the bile. Thus, approximately 90 percent of the ingested drug reaches the large intestine as an intact molecule
Indications
• Rheumatoid arthritis
• Psoriatic arthritis
• Arthritis associated with inflammatory bowel disease (sometimes known as IBD)
• Juvenile idiopathic arthritis.
Dosage
Usual Adult Dose for Rheumatoid Arthritis
Week 1: 500 mg orally once a day in the evening
Week 2: 500 mg orally twice a day (morning and evening)
Week 3: 500 mg orally in the morning and 1000 mg in the evening
Week 4: 1000 mg orally twice a day (morning and evening)
Side Effects
The most common side effects of sulfasalazine are feeling sick, diarrhea, stomach pain, dizziness, headaches, rashes.
Contraindication
Contraindications to sulfasalazine include patients with hypersensitivity to sulfasalazine, its metabolite, sulfonamides, salicylates, or any component of the formulation, intestinal or urinary obstruction, and porphyria.
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