(Levosulpiride 25/ 50 mg Tablet)
(Levosulpiride 25/ 50 mg Tablet)
GERD, IBS, Functional Dyspepsia, Diabetic Gastroparesis
How it works
Levosulpiride is more selective and acts primarily as a dopamine D2 antagonist. Levosulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors. A selective antagonist of dopamine (D2) receptors having activity on both central and peripheral levels. It posses prokinetic and neuroleptic properties. Dopamine (acting through D2 receptors) is an inhibitory neurotransmitter in GIT which; Delays gastric emptying when food is present in stomach. Levosulpiride blocks dopamine (D2) receptors and shows opposite effects to dopamine. It Increases gastric emptying Enhances LES (Lower esopharyngeal sphincter) tone. Levosupiride has centrally action on Chemoreceptor trigger zone (CTZ) producing anti-emetic action.
Indications
GERD, IBS, Functional Dyspepsia, Diabetic Gastroparesis
Dosage
25- 50 mg BID/ TID, 15- 20 minutes before meals.
Side Effects
Headache Fatigue Increased prolactin level in blood Drowsiness Irregular Menstrual Periods Gynecomastia Constipation Abdominal pain and cramps Weight gain Unusual tiredness Increased salivation Fever Excessive Sweating Change in Heart Rate Abnormal Heart Rate
Contraindication
Levosulpiride: Contraindicated in patients with known hypersensitivity to levosulpiride or any of the other constituents of the formulation. Contraindicated in: epilepsy, manic states, cardiac impairment and GI bleeding. Pregnancy Caution when used during pregnancy Lactation Caution when used during lactation Levosulpiride and Other Contraindications Phaeochromocytoma, hyperprolactinaemia, mammary dysplasia, malignant mastopathies,. GI bleeding, mechanical obstruction or perforation PREGNANCY AND LACTATION. Special Precautions: May impair ability to drive or operate machinery.
Copyright © 2020 tasmed
.png)
